Dr. Samuel Conway
Staff Scientist II
Dr. Samuel Conway earned his Ph.D. in the field of organic chemistry from Dartmouth College under the tutelage of Gordon W. Gribble. He spent a number of years as a synthetic chemist, including a stint at the former Avid Therapeutics in Philadelphia, PA, where he developed the promising anti-HBV candidate AT-130, before joining the laboratories of West Pharmaceutical Services. There, in the course of his transition to analytical chemistry, he developed significant insights into the science (and art) of extractables and leachables and is credited with the identification of a number of previously unknown extractables from pharmaceutical rubber. In search of a warmer climate, he moved to North Carolina in 2013, where he headed the extractables and leachables group of Catalent Pharma Solutions before joining the Developmental Support Services team at BD Technologies, where he remains to this day.
DAY 2: DECEMBER 1st, 2023
SESSION: Challenges encountered during the attempted quantification of nitrosodimethylamine (NDMA) in rubber using traditional extraction techniques
◆ The analysis of nitrosamines in drug products is well studied, but little is reported regarding the content of nitrosamines in pharmaceutical rubber.
◆ Highly inconsistent results were obtained using traditional extraction techniques to evaluate the content of nitrosodimethylamine (NDMA) in rubber.
◆ Evidence suggests that NDMA is formed in situ during (and after) extraction.
◆ NDMA may not be present in the rubber in its native form, but may be generated by attempts to detect it.
